Physical Address

304 North Cardinal St.
Dorchester Center, MA 02124

DNA Damage Caused by Sweetener Chemical

Sucralose, which is commonly marketed as Splenda®, is an extensively utilized artificial sweetener. When selecting from a range of artificial sweeteners for your morning coffee, it may be worth reconsidering the yellow packets. This well-known sugar substitute, sold under the brand name Splenda, is approximately 600 times sweeter than regular table sugar. Following the World Health Organization’s declaration regarding the potential carcinogenic nature of aspartame, a recent study conducted by researchers at North Carolina State University has revealed that during digestion, sucralose can produce a chemical called sucralose-6-acetate, which possesses genotoxic properties that can damage DNA. DNA Damage Caused by Sweetener Chemical.

However, recent research has raised concerns regarding its potential health risks. Sucralose, a popular sweetener, has the potential to disrupt your system once it is broken down by your body. This means that a smaller amount is required to achieve the same level of sweetness. Additionally, the study discovered that both sucralose and sucralose-6-acetate can contribute to increased intestinal permeability, commonly referred to as “leaky gut,” allowing substances to enter the bloodstream. DNA Damage Caused by Sweetener Chemical.

Unfavorable Consequences of Sweetener Chemical on DNA Integrity

Studies have indicated that a chemical compound called sucralose-6-acetate, generated during the digestion of sucralose, exhibits genotoxic properties that can result in DNA damage. According to a 2023 article in the Journal of Toxicology and Environmental Health, sucralose-6-acetate is produced by the gut after consuming food or beverages containing sucralose.

DNA Damage Caused by Sweetener Chemical

In a recent study, researchers conducted in vitro experiments by exposing human blood cells to sucralose-6-acetate (S6A), a structural analog of sucralose. Susan Schiffman, the corresponding author of the study, emphasizes that even trace amounts of sucralose-6-acetate in a single daily drink sweetened with sucralose can exceed the European Food Safety Authority’s threshold for toxicological concern regarding genotoxic substances.

Detrimental Effects of Sweetener Chemical on DNA Integrity

Furthermore, trace amounts of sucralose-6-acetate are also present in sucralose itself, even before consumption. When the researchers exposed sucralose-6-acetate to human blood cells, it caused DNA fragmentation, indicating its genotoxic nature. The cells showed signs of DNA damage upon exposure, further supporting its genotoxicity.

Additionally, the study highlights that the amount of sucralose-6-acetate produced as metabolites after consuming sucralose is not taken into consideration. This article explores the findings of these studies and sheds light on the potential adverse health effects associated with sucralose and its metabolites. The study also exposed human gut cells to sucralose-6-acetate, resulting in the disruption of intercellular connections in the gut lining.

Harmful Influence of Chemical in Sweetener on DNA Structure

The findings, published in the Journal of Toxicology and Environmental Health, Part B, also reported that sucralose-6-acetate can impair the integrity of the intestinal barrier, leading to a condition known as “leaky gut.” In light of the mounting evidence regarding potential risks associated with sucralose, Schiffman emphasizes the necessity of reassessing its safety and regulatory status. In another study conducted by researchers, blood cells were subjected to sucralose-6-acetate in vitro, and markers of genotoxicity were monitored.

This disruption of the gut lining could render it more permeable, potentially leading to “leaky gut.” Shortly after the study was published, Splenda clarified that their sweeteners utilize sucralose and do not contain the chemical compound S6A. The sucralose-6-acetate compound also increased the expression of genes related to inflammation, oxidative stress, and cancer in gut cells.

Leave a Reply

Your email address will not be published. Required fields are marked *